Table 3.

Results of multivariable analyses: unique associations of EDSS score increase of ≥1 point with follow-up MSQOL-54 PCS and MCS.

	Estimate (SE)	t-value	p value
6 months
MSQOL-54 PCS, n = 279
New to DMD	−4.53 (1.89)	−2.40	0.017
EDSS change ≥1 point	−7.95 (2.34)	−3.40	0.0008
MSQOL-54 MCS, n = 302
Greater than secondary education	5.00 (1.80)	2.78	0.006
EDSS change ≥1 point	−4.40 (2.82)	−1.56	NS
12 months
MSQOL-54 PCS, n = 248
EDSS change ≥1 point	−5.34 (2.49)	−2.14	0.033
MSQOL-54 MCS, n = 269
Greater than secondary education	4.07 (1.99)	2.05	0.042
EDSS change ≥1 point	−2.88 (2.75)	−1.05	NS
18 months
MSQOL-54 PCS, n = 210
Age	−0.34 (0.12)	−2.86	0.005
EDSS change ≥1 point	−7.36 (2.84)	−2.59	0.010
MSQOL-54 MCS, n = 229
New to DMD	6.80 (2.89)	2.35	0.019
EDSS change ≥1 point	−4.35 (3.04)	−1.43	NS
24 months
MSQOL-54 PCS, n = 181
EDSS change ≥1 point	−6.70 (2.74)	−2.45	0.016
MSQOL-54 MCS, n = 196
Greater than secondary education	6.03 (2.53)	2.38	0.018
EDSS change ≥1 point	−2.67 (2.97)	−0.90	NS

Significant associations between EDSS change ≥1 point and follow-up MSQOL-54 PCS or MCS are highlighted in bold. The generalized linear model procedure was used. All models included age, sex, highest level of education (not greater than or greater than secondary), whether naïve to DMD at study onset, whether terminated the study early, and baseline HRQoL measure score. Baseline HRQoL measure score was significant in all models.

DMD, disease-modifying drug; EDSS, Expanded Disability Status Scale; HRQoL, health-related quality of life; MCS, mental health composite score; MSQOL-54, Multiple Sclerosis Quality of Life-54; NS, not statistically significant; PCS, physical health composite score; SE, standard error.