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PK/PD model simulation of the experimental rifampin dose-fractionation study for TB infected BALB/c mice described in Jayaram et al. [12]. Individual data points (⋄) were PK/PD model generated, with each point obtained from the simulation of total lung CFU’s and corresponding PK/PD index calculated from simulated plasma concentrations for each dosage regimen of the dose-fractionation study. Solid lines are Emax equation fits (Table 2) to the PK/PD model generated data points.
