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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2015 May 31;42(4):375–389. doi: 10.1007/s10928-015-9419-z

Fig. 4.

Fig. 4

PK/PD model simulations during days 13 to 44 of pulmonary bacterial load, cytokine concentrations, and macrophage and T cell densities (cells per mL of lung tissue) following a two-week daily 10 mg/kg oral dose of rifampin beginning on day 28 post-aerosol infection in TB-infected BALB/c mice. a Bacterial load (sum of intra- and extracellular bacteria). b Cell densities of infected (MI ) and activated (MA) macrophages. c Cytokine (IL-10, IL-2, IL-12, and IFN-γ) concentrations. d Cell densities of CD4+ and CD8+ T cells.