Table 3.

Fit of $E=E_{\mathit{max}}(1-X^n/(X_{50}^n+X^n))$ to PK/PD model predicted (Figure 2) and experimentally observed [12] mouse rifampin dose-fractionation data (E = log₁₀ CFU, E_max = maximum E, X is a PK/PD index, X₅₀ is the value of X at E = E_max/2, and n is a shape parameter.)

X	Emax		X50		n		R2		CV%
	Pred.	Obs.	Pred.	Obs.	Pred.	Obs.	Pred.	Obs.	Pred.	Obs.
AUC24/MIC	5.9	5.9	4.3 ×103	3.9 ×103	0.65	0.70	0.95	0.95	5.4	6.0
Cmax/MIC	5.9	6.2	5.0 ×102	2.8 ×102	0.63	0.57	0.78	0.81	11	9.1
T>MIC	5.8	5.7	1.1 ×102	1.1 ×102	4.8	11	0.66	0.46	14	18

R²: coefficient of determination.

CV%: percent coefficient of variation (of root mean square error).

Pred.: calculated from PK/PD model predicted log₁₀ CFU v.s. X shown in Figure 2

Obs.: calculated from experimentally observed log₁₀ CFU v.s. X reported in Jayaram et al. [12]