Table 5.
Baseline PD model parameters that were not updated in the Bayesian calibration procedure. The parameter names, descriptions, and values are from Friedman et al. [24].
| Parameter (units) | Value | |
|---|---|---|
| αE | Growth rate of BE (1/d) | 0 |
| αA | Growth rate of BA (1/d) | 0 |
| k2 | Burst rate of infected macrophages (1/d) | 0.81139 |
| k3 | Activation rate of infected macrophages (1/d) | 0.023415 |
| k4 | Deactivation rate of activated macrophages (1/d) | 0.28876 |
| k5 | Take up of BE by activated macrophages (mL/cell/d) | 8.1301 ×10−5 |
| k6 | Rate of activation of resting macrophages (1/d) | 0.077068 |
| k7 | IL-10 production rate by infected macrophages (pg/mL/cell) | 0.50610 |
| k8 | IL-12 production rate by activated macrophages (pg/cell/d) | 0.28503 |
| k9 | IL-12 production rate by resting macrophages (pg/cell/d) | 5 ×10−4 |
| k10 | IL-2 production rate by T 4 (pg/cell/d) | 2.1873 ×10−4 |
| k11 | Loss of IL-2 due to proliferation of T 4 (pg/cell/d) | 1.6383 ×10−4 |
| k12 | Loss of IL-2 due to proliferation of T 8 (pg/cell/d) | 1.6383 ×10−5 |
| k13 | Rate of proliferation of T 4 by IL-2 (mL/pg/d) | 0.16383 |
| k14 | Rate of proliferation of T 8 by IL-2 (mL/pg/d) | 0.016383 |
| c2 | Saturation for activation of infected macrophages (pg/mL) | 50 |
| c3 | IFN-γ inhibition for deactivation of activated macrophages | 3 |
| c4 | Saturation for deactivation of activated macrophages (pg/mL) | 1 |
| c5 | Saturation for activation of resting macrophages (cell/mL) | 105 |
| c6 | IFN-γ saturation for activation of resting macrophages (pg/mL) | 20 |
| c7 | Saturation for IL-10 inhibition by IL-10 (pg/mL) | 5000 |
| c8 | Saturation for IL-12 inhibition by IL-10 (pg/mL) | 200 |
| c9 | Saturation for IL-12 production by resting macrophages (cell/mL) | 5000 |
| c10 | Saturation for T cell proliferation by IL-2 (pg/mL) | 50 |
| c11 | Saturation for IFN-γ production by T cells and IL-12 (cell/mL) | 50 |
| n1 | Average number of BI in an infected macrophage | 20 |
| n2 | Average number of BA in an activated macrophage | 5 |
| n3 | Threshold at which a resting macrophage becomes infected | 10 |
| μMA | Death rate of activated macrophages (1/d) | 0.015 |
| μMI | Death rate of infected macrophages (1/d) | 0.2 |
| μ10 | Decay rate of IL-10 (1/d) | 7.23 |
| μ12 | Decay rate of IL-12 (1/d) | 1.188 |
| μ2 | Decay rate of IL-2 (1/d) | 1.188 |
| μγ | Decay rate of IFN-γ (1/d) | 3 |
| μT4 | Death rate of T 4 (1/d) | 0.33 |
| μT8 | Death rate of T 8 (1/d) | 0.33 |
| λu | Rate of IFN- γ production by T 4 (pg/cell/day) | 1.24 ×10−4 |
| λy | Rate of IFN- γ production by T 8 (pg/cell/day) | 1.24 ×10−4 |