Table 6.
Baseline anatomical/physiological PBPK model parameters that were not updated in the Bayesian calibration procedure. The parameter names, descriptions, and values are from Lyons et al. [23].
| Parameter (units) | Value | |
|---|---|---|
| QCC | Cardiac output (L/d/kg0.75) | 396 |
| kF | Gut lumen transit rate (1/d) | 14.4 |
| Fractional tissue volumesa | ||
| VLUC | Lung | 0.007 |
| VBRC | Brain | 0.017 |
| VFC | Fat | 0.07 |
| VHC | Heart | 0.005 |
| VMC | Muscle | 0.384 |
| VBC | Bone | 0.107 |
| VSKC | Skin | 0.165 |
| VKC | Kidney | 0.017 |
| VSC | Spleen | 0.0035 |
| VGC | Gut | 0.042 |
| VLC | Liver | 0.055 |
| VVC | Venous blood | 0.0327 |
| VAC | Arterial blood | 0.0163 |
| VCRC | Carcass | 0.0785 |
| Fractional blood flowsb | ||
| QBRC | Brain | 0.033 |
| QFC | Fat | 0.09 |
| QHC | Heart | 0.066 |
| QMC | Muscle | 0.159 |
| QBC | Bone | 0.11 |
| QSKC | Skin | 0.058 |
| QKC | Kidney | 0.091 |
| QSC | Spleen | 0.01 |
| QGC | Gut | 0.13 |
| QLAC | Hepatic artery | 0.02 |
| QCRC | Carcass | 0.233 |
a
Fraction of body weight.
b
Fraction of cardiac output.