. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2015 May 31;42(4):375–389. doi: 10.1007/s10928-015-9419-z

Table 7.

Baseline rifampin-dependent PBPK model parameters that were not updated in the Bayesian calibration procedure. The parameter names, descriptions, and values are from Lyons et al. [23].

	Parameter (units)	Value
f_R	fractional renal clearance	0.19
k_r	Gut reabsorption rate (1/d)	4.08
Partition coefficients
BP	Blood/plasma	0.9
P_LU	Lung/blood	0.49
P_BR	Brain/blood	0.11
P_F	Fat/blood	0.34
P_H	Heart/blood	0.74
P_B	Bone/blood	0.22
P_SK	Skin/blood	0.76
P_K	Kidney/blood	0.59
P_S	Spleen/blood	0.25
P_G	Gut/blood	0.74
P_L	Liver/blood	3.1
P_CR	Carcass/blood	0.59