Fig. 2.
Anillin depletion disrupts the integrity of epithelial adherens junctions. DU145 cells were transfected with either control or anillin-specific siRNAs and immunolabeled for adherens junction proteins E-cadherin, Cadherin 6, and β-catenin on day 4 post-transfection. Arrows indicate accumulation of all adherens junction proteins at the areas of cell–cell contact in control cells. Arrowheads highlight the disappearance of these proteins from intercellular junctions after anillin depletion. Scale bar 20 µm