Fig. 1.

In vitro assessment of triple- and quadruple-coated (EUDRAGIT®L100-55) gelatin capsules

Triple-coated (EUDRAGIT®L100-55) capsule integrity following incubation for 60 (a), 90 (b), and 120 min (c) at pH 1.0 and then 30 min at pH 7.0 (d). Quadruple-coated (EUDRAGIT®L100-55) capsule integrity following incubation for 60 (e), 90 (f), and 120 min (g) at pH 1.0 and then 30 min at pH 7.0 (h). All incubations were conducted at 37 °C with 100 r/min rotation. All pictures are plan views of the dissolution cups. Blue areas indicate dye content release