Fig. 2.

¹³CO₂ release in the breath of pigs following dosing with either liquid or enteric-coated capsules containing powdered ¹³C-acetate

(a) In the first set of small-scale pilot studies, pigs (n=1 per dose) were gavaged with 250, 125, or 65 mg of ¹³C-acetate dissolved in 100 ml water. (b) In the second set of pilot studies, pigs were gavaged with 250 mg of powdered ¹³C-acetate in a gelatin capsule quadruple-coated with EUDRAGIT®L100-55 (n=4) or with 250 mg of ¹³C-acetate dissolved in 100 ml acidified water simultaneously with 250 mg of powdered ¹³C-acetate enclosed in a double DRcaps®quadruple-coated with EUDRAGIT®L100-55 (n=2). Breath samples were collected throughout the duration of the study and assessed for the presence of ¹³CO₂ and expressed as delta/baseline. Data are represented as mean and standard error of the mean