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. 2015 Jul 2;6:7353. doi: 10.1038/ncomms8353

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(a) Reconstitution of PTEN reduced the cell migration of both CNE1-BART1 and 5-8F-BART1 cells. (b) Reinstallation of PTEN reduced the cell invasion of both CNE1-BART1 and 5-8F-BART1 cells. (c) Restitution of PTEN decreased the phosphorylation levels of p-Akt, p-FAK, p130^Cas, p-Shc and p-ERK1/2 in both CNE1-BART1 and 5-8F-BART1 cells (PTEN versus NC). (d) Restoration of PTEN dosage increased the expression of E-cadherin but decreased the expression of either N-cadherin or vimentin in both CNE1-BART1 and 5-8F-BART1 cells (PTEN versus NC). Original magnification, × 200; scale bar, 25 μm. Student's t-test, mean±s.e.m., N=3. ***P<0.001.