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. 2015 Jul 21;21(27):8271–8283. doi: 10.3748/wjg.v21.i27.8271

Table 2.

Cholangiocarcinoma studies n (%)

Author Type of microsphere Type of mets (patients) Response criteria Response Median OS
(publish date and study type) (average dosage or activity) @ 1st assessment
Ibrahim et al[69] Therasphere ICC (24) WHO 6 (27) PR 14.9 mo
(10/2008, PC) (median 105.1 Gy) @ 1 mo 15 (68) SD
1 (5) PD 31.8 mo (solitary)
2 lost 6.1 mo (extrahepatic disease)
Saxena et al[71] SIR-Spheres ICC (25) RECIST 6 (26) PR 9.3 mo
(2/2010, PC) (mean 1.76 Gbq) @ 8.1 mo (median) 11 (48) SD
5 (22) PD
2 lost
Haug et al[68] SIR-Spheres ICC (26) RECIST 5 (22) PR 11.7 mo
(6/2011, PC) (no dosage info) @ 2.8 mo 15 (65) SD
3 (13) PD
3 lost
Hoffmann et al[3] SIR-Spheres ICC (33) RECIST 12 (36) PR 22 mo
(2/2012, RS) (median 1.54 Gbq) @ 3 mo 17 (52) SD
4 (12) PD
Rafi et al[70] SIR-Spheres ICC (19) RECIST 2 (11) PR 11.5 mo
(4/2013, PC) (mean 1.20 Gbq) @ 3 mo 13 (68) SD
4 (21) PD
Mouli et al[74] Therasphere ICC (46) WHO 11 (25) PR No median OS
(8/2013, PC) (no dose info) Note: overlaps with Ibrahim et al @ 1 mo 33 (73) SD 1 (2) PD 14.6 mo (solitary) 5.7 mo (multifocal)
Camacho et al[72] SIR-Spheres ICC (21) RECIST RECIST 16.3 mo
(2/2014, PC) (no dose info) mRECIST 1 (4.7) PR
EASL 16 (76.2) SD
@ 1 mo 4 (19.1) PD
mRECIST
13 (62.0) PR
4 (19.0) SD
4 (19.0) PD
EASL
2 (9.5) PR
15 (71.4) SD
4 (19.1) PD
Filippi et al[73] SIR-Spheres ICC (18) PERCIST 14 (82.3) PR 14.8 mo
(8/2014, PC) (not given) @ unspecified 3 (17.6) SD

ICC: Intrahepatic cholangiocarcinoma; PC: Prospective cohort study; RS: Retrospective study; CR: Complete response; PR: Progressive response; PD: Progressive disease; SD: Stable disease; OS: Overall survival; OR: Overall response.