Table 2.
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Ibrahim et al[69] | Therasphere | ICC (24) | WHO | 6 (27) PR | 14.9 mo |
(10/2008, PC) | (median 105.1 Gy) | @ 1 mo | 15 (68) SD | ||
1 (5) PD | 31.8 mo (solitary) | ||||
2 lost | 6.1 mo (extrahepatic disease) | ||||
Saxena et al[71] | SIR-Spheres | ICC (25) | RECIST | 6 (26) PR | 9.3 mo |
(2/2010, PC) | (mean 1.76 Gbq) | @ 8.1 mo (median) | 11 (48) SD | ||
5 (22) PD | |||||
2 lost | |||||
Haug et al[68] | SIR-Spheres | ICC (26) | RECIST | 5 (22) PR | 11.7 mo |
(6/2011, PC) | (no dosage info) | @ 2.8 mo | 15 (65) SD | ||
3 (13) PD | |||||
3 lost | |||||
Hoffmann et al[3] | SIR-Spheres | ICC (33) | RECIST | 12 (36) PR | 22 mo |
(2/2012, RS) | (median 1.54 Gbq) | @ 3 mo | 17 (52) SD | ||
4 (12) PD | |||||
Rafi et al[70] | SIR-Spheres | ICC (19) | RECIST | 2 (11) PR | 11.5 mo |
(4/2013, PC) | (mean 1.20 Gbq) | @ 3 mo | 13 (68) SD | ||
4 (21) PD | |||||
Mouli et al[74] | Therasphere | ICC (46) | WHO | 11 (25) PR | No median OS |
(8/2013, PC) | (no dose info) | Note: overlaps with Ibrahim et al | @ 1 mo | 33 (73) SD 1 (2) PD | 14.6 mo (solitary) 5.7 mo (multifocal) |
Camacho et al[72] | SIR-Spheres | ICC (21) | RECIST | RECIST | 16.3 mo |
(2/2014, PC) | (no dose info) | mRECIST | 1 (4.7) PR | ||
EASL | 16 (76.2) SD | ||||
@ 1 mo | 4 (19.1) PD | ||||
mRECIST | |||||
13 (62.0) PR | |||||
4 (19.0) SD | |||||
4 (19.0) PD | |||||
EASL | |||||
2 (9.5) PR | |||||
15 (71.4) SD | |||||
4 (19.1) PD | |||||
Filippi et al[73] | SIR-Spheres | ICC (18) | PERCIST | 14 (82.3) PR | 14.8 mo |
(8/2014, PC) | (not given) | @ unspecified | 3 (17.6) SD |
ICC: Intrahepatic cholangiocarcinoma; PC: Prospective cohort study; RS: Retrospective study; CR: Complete response; PR: Progressive response; PD: Progressive disease; SD: Stable disease; OS: Overall survival; OR: Overall response.