Table 4.
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Michl et al[43] | SIR-Spheres | Pancreatic (19) | RECIST | 9/13 (64.3) PR | 9 mo |
(12/2013, RS) | (1.0-2.5 Gbq) | @ 2.6 mo (median) | 4/13 (35.7) PD | ||
6 lost | |||||
Cao et al[32] | SIR-Spheres | Pancreatic (7) | RECIST | 2 (40) PR | No median OS |
(11/2010, RS) | (no dosage info) | @ 1-2 mo | 1 (20) SD | 1 patient survived to 15 mo | |
2 (40) PD | |||||
2 lost | |||||
Pöpperl et al[45] | SIR-Spheres | Pancreatic (1, data extracted from larger study) | PET | 1 (100) Regression | None |
(4/2005, PC) | (mean 2.27 Gbq) | @ 3 mo |
PC: Prospective cohort study; RS: Retrospective study; CR: Complete response; PR: Progressive response; PD: Progressive disease; SD: Stable disease; OS: Overall survival; OR: Overall response.