Table 6.
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Gaba et al[36] | Therasphere | Squamous cell lung cancer (2) | PET CT | 2 (100) CR | Patient 1: Alive 11 mo after SIRT |
(8/2012, case report) | (1.57-3 Gbq) | @ 2-3 mo | Patient 2: Alive 2 mo after SIRT | ||
Murthy et al[44] | SIR-Spheres | Lung cancer (6) | Unspecified | 1 (17) PR | 2.7 mo |
(2/2008, RS) | (no dosage info) | 2 carcinoids 3 adenocarcinomas | @ unspecified | 1 (17) “minor response” | |
1 small cell carcinoma | 1 (17) SD | ||||
3 (50) PD | |||||
Reiner et al[46] | SIR-Spheres | NSCLC (1, data extracted from larger study) | RECIST 1.1 | 1 (100) CR/PR | None |
(1/2014, PC) | (mean 1.5 Gbq) | @ 4 mo |
SIRT: Selective internal radiation therapy; RS: Retrospective study; PC: Prospective cohort study; CR: Complete response; PR: Progressive response; PD: Progressive disease; SD: Stable disease; OS: Overall survival.