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. 2015 Jul 21;21(27):8271–8283. doi: 10.3748/wjg.v21.i27.8271

Table 6.

Lung or thoracic cancer studies n (%)

Author Type of microsphere Type of mets (patients) Response criteria Response Median OS
(publish date and study type) (average dosage or activity) @ 1st assessment
Gaba et al[36] Therasphere Squamous cell lung cancer (2) PET CT 2 (100) CR Patient 1: Alive 11 mo after SIRT
(8/2012, case report) (1.57-3 Gbq) @ 2-3 mo Patient 2: Alive 2 mo after SIRT
Murthy et al[44] SIR-Spheres Lung cancer (6) Unspecified 1 (17) PR 2.7 mo
(2/2008, RS) (no dosage info) 2 carcinoids 3 adenocarcinomas @ unspecified 1 (17) “minor response”
1 small cell carcinoma 1 (17) SD
3 (50) PD
Reiner et al[46] SIR-Spheres NSCLC (1, data extracted from larger study) RECIST 1.1 1 (100) CR/PR None
(1/2014, PC) (mean 1.5 Gbq) @ 4 mo

SIRT: Selective internal radiation therapy; RS: Retrospective study; PC: Prospective cohort study; CR: Complete response; PR: Progressive response; PD: Progressive disease; SD: Stable disease; OS: Overall survival.