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. 2014 Dec 22;21(13-14):1973–1981. doi: 10.1089/ten.tea.2014.0381

FIG. 3.

FIG. 3.

Accumulation of superficial zone protein (SZP) stimulated by TGF-β1 in the presence of exogenous GAGs. Monolayer superficial zone articular chondrocyte cultures were treated for 4 days with either 0.3 or 1 ng/mL of TGF-β1 in the absence or presence of 30 μg/mL of GAGs. (A) Treatment of TGF-β1 (0.3 ng/mL) in the presence of exogenous heparan sulfate (HS) or heparin significantly increased SZP accumulation compared with untreated control groups. (B) Treatment of TGF-β1 (1 ng/mL) in the presence of exogenous chondroitin sulfate (CS) significantly increased SZP accumulation compared with untreated control groups. Results presented as SZP protein fold increase compared with untreated controls. Values presented as mean±standard error. *p<0.05 compared with untreated control.