Table 3.

Genotype and Allele Frequencies of 10 Single-Nucleotide Polymorphisms in Peroxisome Proliferator-Activated Receptor Genes as well as the Association with the Level of Low-Density Lipoprotein-Cholesterol

SNPs	Alleles and genotypes	Frequencies, n (%)	Mean difference (95% CI)a	p-Valuea	Mean difference (95% CI)b	p-Valueb
rs135539	AA	484 (59)	0	0.29	0	0.12
	AC+CC	336 (41)	0.09 (−0.08 to 0.26)		0.13 (−0.03 to 0.30)
	A	1242 (75.7)
	C	398 (24.3)
rs1800206	LL	622 (75.9)	0	<0.0001	0	<0.0001
	LV+VV	198 (24.1)	1.20 (1.02 to 1.38)		1.16 (0.99 to 1.34)
	L	1435 (87.5)
	V	205 (12.5)
rs4253778	GG	615 (75)	0	0.13	0	0.11
	GC+CC	205 (25)	−0.15 (−0.35 to 0.04)		−0.15 (−0.34 to 0.03)
	G	1404 (85.6)
	C	236 (14.4)
rs2016520	TT	388 (47.3)	0	0.91	0	0.94
	TC+CC	432 (52.7)	−0.01 (−0.18 to 0.16)		0.01 (−0.16 to 0.17)
	T	1142 (69.6)
	C	498 (30.4)
rs9794	CC	498 (60.7)	0	0.066	0	0.018
	CG+GG	322 (39.3)	0.16 (−0.01 to 0.33)		0.20 (0.03 to 0.37)
	C	1278 (77.9)
	G	362 (22.1)
rs10865710	CC	367 (44.8)	0	0.03	0	0.013
	CG+GG	453 (55.2)	−0.19 (−0.36 to −0.02)		−0.21 (−0.37 to −0.04)
	C	1099 (67)
	G	541 (33)
rs1805192	PP	459 (56)	0	<0.0001	0	0.0002
	PA+AA	361 (44)	0.39 (0.22 to 0.56)		0.32 (0.15 to 0.48)
	P	1206 (73.5)
	A	434 (26.5)
rs4684847	CC	519 (63.3)	0	0.81	0	0.78
	CT+TT	301 (36.7)	0.02 (−0.15 to 0.20)		0.02 (−0.14 to 0.19)
	C	1295 (79)
	T	345 (21)
rs709158	AA	410 (50)	0	0.0009	0	0.0025
	AG+GG	410 (50)	0.28 (0.12 to 0.45)		0.25 (0.09 to 0.41)
	A	1154 (70.4)
	G	486 (29.6)
rs3856806	CC	418 (51)	0	<0.0001	0	0.0001
	CT+TT	402 (49)	0.37 (0.21 to 0.54)		0.32 (0.16 to 0.48)
	C	1162 (70.9)
	T	478 (29.1)

^aWithout adjustment.

^bAdjusted for alcohol, BMI, and WC.

CI, confidence interval.