Table 4.

Multilocus Interaction Model for Low-Density Lipoprotein-Cholesterol by Generalized Multifactor Dimensionality Reduction Method

No. of loci	Best combination	Testing accuracy	Cross-validation consistency	p-Value
Model Aa
2	rs1800206 rs1805192	0.7257	9/10	10 (0.0010)
3	rs1800206 rs1805192 rs709158	0.7388	9/10	10 (0.0010)
4	rs1800206 rs1805192 rs709158 rs3856806	0.7355	6/10	10 (0.0010)
5	rs1800206 rs2016520 rs9794 rs1805192 rs4684847	0.6791	4/10	10 (0.0010)
6	rs1800206 rs9794 rs10865710 rs1805192 rs709158 rs3856806	0.6478	3/10	10 (0.0010)
7	rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs709158 rs3856806	0.6231	4/10	10 (0.0010)
8	rs135539 rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs709158 rs3856806	0.6084	6/10	9 (0.0107)
9	rs135539 rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs4684847 rs709158 rs3856806	0.5707	6/10	8 (0.0547)
10	rs135539 rs1800206 rs4253778 rs2016520 rs9794 rs10865710 rs1805192 rs4684847 rs709158 rs3856806	0.5614	10/10	6 (0.3770)
Model Bb
2	rs1800206 rs1805192	0.7042	10/10	10 (0.0010)
3	rs1800206 rs1805192 rs4684847	0.6938	5/10	10 (0.0010)
4	rs1800206 rs1805192 rs4684847 rs3856806	0.6846	4/10	10 (0.0010)
5	rs1800206 rs9794 rs1805192 rs709158 rs3856806	0.6344	6/10	10 (0.0010)
6	rs135539 rs1800206 rs9794 rs10865710 rs1805192 rs3856806	0.5868	5/10	10 (0.0010)
7	rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs709158 rs3856806	0.6252	10/10	10 (0.0010)
8	rs135539 rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs709158 rs3856806	0.5763	6/10	9 (0.0107)
9	rs135539 rs1800206 rs2016520 rs9794 rs10865710 rs1805192 rs4684847 rs709158 rs3856806	0.5244	8/10	8 (0.0547)
10	rs135539 rs1800206 rs4253778 rs2016520 rs9794 rs10865710 rs1805192 rs4684847 rs709158 rs3856806	0.5683	10/10	8 (0.0547)

Adjusted for alcohol, BMI, and WC.

^aLDL-C was represented as a continuous variable.

^bLDL-C was represented as a dichotomous variable (the cutoff point is 4.14 mM).