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. 2015 Jul 1;35(7):499–512. doi: 10.1089/jir.2015.0015

FIG. 2.

FIG. 2.

IL-35 signaling in T and B cells. Production of IL-35 by Foxp3+ T cells and CD19+CD138hi B cells inhibits T- and B-cell proliferation. Signaling through gp130 and IL12Rβ2 homodimers inhibits T-cell proliferation, while formation of the gp130/IL12Rβ2 heterodimer is required for both inhibition of T-cell proliferation and generation of iTr35 cells (left panel). B cells respond to IL-35 through the IL27Rα/IL12Rβ2 heterodimer leading to expansion of IL-10 and IL-35-producing Bregs that function to inhibit cellular proliferation (right panel).