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(A) Micro-computed tomography images of calvarial defects treated with Ap-PLGA scaffolds loaded with various doses of phenamil (0, 100, 300, 600, 1000, and 1500 μM). Quantification of percentage area (B) and volume (C) bone regeneration in calvarial defects. *Significant higher bone formation compared with control (*p<0.05).
