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(A) Micro-computed tomography images of calvarial defects treated with Ap-PLGA scaffolds loaded with various doses of BMP-2 (30, 60, and 100 μg/mL) in the presence or absence of phenamil (300 μM). Quantification of percentage area (B) and volume (C) bone regeneration in calvarial defects (*p<0.05).
