Table 1.

Targets of Salmonella effectors in the reconstructed network.

Host protein	Function	Pathogen effectors	Type of the node in the network*
CDC42	Actin filament bundle assembly	SopB, SopE	intermediate
MTOR	Protein serine/threonine kinase activity	AvrA	intermediate
RHOA	Actin cytoskeleton organization	SifA, SseJ	intermediate
YWHAG	Negative regulation of protein serine/threonine kinase activity	SspH2	intermediate
TP53	Apoptotic activity	AvrA	intermediate
TLN1	Structural constituent of cytoskeleton	SseL	intermediate
KLC1	Microtubule motor activity	PipB2	pp-hit
FLNA	Actin cytoskeleton reorganization	SseI, SrfH, SspH2	pp-hit
CTNNB1	Cytoskeletal anchoring at plasma membrane	AvrA	pp-hit
VIM	Intermediate filament organization	SptP	pp-hit
IQGAP1	Ras GTPase activator activity	SseI, SrfH	pp-hit
JUP	Cytoskeletal anchoring at plasma membrane	SseF	pp-hit
KRT18	Intermediate filament cytoskeleton organization	SipC or SspC	pp-hit
MAPK1	Activation of MAPK activity	AvrA, SpvC	pp-hit
OSBPL9, OSBPL10, OSBPL11	Lipid transport	SseL	pp-hit (except OSBPL11)
STX1A, STX3, STX4, STX5, STX7, STX12, STXBP5	Intracellular protein transport		intermediate (except STX7, STX12)

^*Intermediate, Steiner node; pp-hit, Phosphoproteomic hit.