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. 2015 May 19;172(14):3484–3494. doi: 10.1111/bph.13156

Figure 4.

Figure 4

Eugenol reduces systemic BP by activating TRPV4 channels. (A) Representative recording illustrating the effects of eugenol (5 mg·kg−1, i.v.) on BP. (B) Representative trace showing that HC-067047 (9 μg·kg−1, i.v.) attenuates the prolonged reduction in BP induced by eugenol (5 mg·kg−1, i.v.). (C) Mean data for the effects of eugenol (5 mg·kg−1, i.v.) on MAP in the absence (n = 5) or presence (n = 5) of HC-067047 (9 μg·kg−1, i.v.). *§P < 0.05 versus control and Eug 5 mg·kg−1 respectively. (D) Mean data for effects of eugenol (5 mg·kg−1, i.v.) on heart rate in the absence (n = 5) or presence (n = 5) of HC-067047 (9 μg·kg−1, i.v.). *P < 0.05 versus control.