Figure 7.

Leptin-induced pSTAT3 in the PMV of 2C-null mice. (A–B) pSTAT3 immunohistochemical staining in the PMV of chow-fed 2C-null mice receiving a single bolus i.p. injection of saline (A) or 0.5 mg·kg⁻¹ leptin (B). Note that representative images from WT mice have been included as the ‘lean’ group (from Figure 4). (C) Quantification of number of pSTAT3-positive neurons in the PMV of WT or 2C-null littermates. Data are presented as mean ± SEM. n = 3 in each group. #P < 0.05 between saline and leptin within the same genotype; *P < 0.05 between WT and 2C-null within the same injection groups; two way anova followed by the post hoc Newman–Keuls Student's tests.