Figure 4.

Effect of olodaterol on acetylcholine-induced bronchoconstriction in C57BL/6 mice. One hour after exposure of the animals to an olodaterol aerosol (0.001–10 mg·mL⁻¹) for 5 min, a transient bronchoconstriction was elicited by i.v. injection of acetylcholine (125–1000 μg·kg⁻¹ body weight). The AUC of resistance increase between 125 and 1000 μg·kg⁻¹ acetylcholine of the placebo group was defined as 100%. Data shown are means ± SEM (n = 4–7 animals per group).