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. 2015 Jun 4;172(14):3565–3578. doi: 10.1111/bph.13146

Figure 7.

Figure 7

Induction of apoptosis and SHP-1 and suppression of p-BCR-ABL expression in K562-inoculated tumour tissues. (A) Immunohistochemical analysis of cleaved caspase 3, SHP-1 and p-BCR-ABL in CML tumor tissues from mice. (B) The expression levels of cleaved caspase 3, SHP-1 and p-BCR-ABL were quantified by the ratio of stained cell numbers versus total counted numbers. *P < 0.05; **P < 0.01; ***P < 0.001, significantly different from untreated control. (C) Scheme for antitumor mechanism of EGCG-MP via induction of SHP-1 and inhibition of p-BCR-ABL and p-STAT3 in CML.