Figure 5.

Effect of SAR7334 on hypoxia-induced vasoconstriction in isolated perfused and ventilated lungs. (A) Acute hypoxic pulmonary vasoconstriction (HPV) was assessed as the increase in pulmonary artery pressure (ΔPAP) upon hypoxic ventilation in isolated perfused mouse lungs. Data were normalized to the reference pressure response in the absence of SAR7334 for each experiment. SAR7334 dose-dependently reduced the strength of HPV. SAR7334 had no significant effect on normoxic vascular tone (not shown). Data shown are means ± SEM (n = 5). ***P < 0.001, significantly different from control response. (B) Original recordings of PAP in the absence (left) or presence (right) of 1 μM SAR7334. Hypoxic challenge is indicated by the bars.