Figure 7.

SAR7334 does not affect BP in conscious SHR. Mean arterial pressure (MAP) was measured telemetrically in SHR. The time course of average MAP in vehicle-treated (n = 8) and SAR7334-treated (n = 5) groups is illustrated (A). Statistical comparison of MAP in vehicle- and SAR7334-treated animals 24 h before compound application (pre) and after treatment (post) did not show a time-dependent or treatment-related effect or a significant interaction of both factors (repeated measures two-way anova) (B).