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. 2015 Jul 20;5:12366. doi: 10.1038/srep12366

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A After infection with lentiviruses, over 80% of the transduced cells (Lv-GFP group and Lv-TMPRSS4 group) showed green fluorescence under the fluorescence microscope. Cells transfected with TMPRSS4 altered from an epithelial cobblestone appearance to an elongated/irregular shape, together with enhanced expression of vimentin and reduced expression of E-cadherin in immunofluorescence assay, suggesting an epithelial-mesenchymal transition of TMPRSS4 transfected cells; B PCR revealed that cells transfected with TMPRSS4 showed significantly enhanced expression of TMPRSS4, vimentin, snail and slug, but reduced expression of E-cadherin; C TMPRSS4 transfection slightly inhibited the in vitro proliferation of HCC cells. Bars, SD. *P < 0.05.