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. 2015 Jul 20;5:12366. doi: 10.1038/srep12366

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A Closing of the wound was much faster in Lv-TMPRSS4 group than in control and Lv-GFP group; B,C The number of invading or attached cells increased several-fold over control and vector-transfected cells when TMPRSS4 was overexpressed; D Statistical analyses confirmed that cells transfected with TMPRSS4 showed significantly enhanced ability to migration, adhesion and invasion; E Compared with control and Lv-GFP group, TMPRSS4-overexpression cells displayed significantly enhanced activation of ERK1/2, together with reduced expression of E-cadherin and enhanced expression of fibronectin, vimentin, snail and slug, which can be significantly reversed by U0126, the inhibitor of ERK1/2; F After U0126 treatment, the morphologies of TMPRSS4 overexpression cells were altered from an elongated/irregular shape to an epithelial cobblestone appearance; GU0126 treatment resulted in significant suppression of cell invasion. Bars, SD. *P < 0.05.