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. 2015 Jun 29;112(28):E3729–E3737. doi: 10.1073/pnas.1500682112

Fig. 5.

Fig. 5.

Freezing behavior does not alter mPFC firing rate. Freezing behavior in both vehicle-treated (Left) and propranolol-treated (Right) rats was not markedly different during the immediate postshock period on day 1 compared with the immediate post-CS period on day 2 [values represent the average freezing immediately following the last US (day 1) or CS (day 2)]. Despite similarities in day 1 and day 2 freezing, normalized firing rate during the first 20 s following the last US (day 1) or CS (day 2) was dramatically elevated in both IL and PL on day 1 relative to day 2 in vehicle-treated rats (Left). This effect was mitigated by propranolol treatment (Right). Hence, marked differences in firing rate in the mPFC cannot be attributed to freezing behavior per se, because both posttrial periods (on day 1 and day 2) yielded similar and high levels of freezing. All values are means ± SEM.