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. 2015 Jun 29;112(28):E3729–E3737. doi: 10.1073/pnas.1500682112

Fig. S3.

Fig. S3.

Propranolol stabilizes single-unit firing in IL after CS delivery. (A) Day 2 experimental design. (B) Propranolol-treated rats (red circles) did not exhibit altered freezing relative to vehicle-treated rats (white circles) when averaged across the entire session. (C) After CS presentation, the majority of mPFC neurons in vehicle-treated rats showed decreases in firing rate, and this was most pronounced in IL neurons. A significantly greater proportion of IL neurons was suppressed in the vehicle- compared with propranolol-treated animals. (D and E) Unlike day 1, the normalized firing rate of PL neurons in both vehicle- and propranolol-treated rats exhibited little change after presentation of the aversive CS. Interestingly, IL firing rate was depressed by CS presentations, and this effect was mitigated by propranolol. Insets show normalized firing in the first 20-s bin after the last CS for neurons from vehicle- (white bars) and propranolol-treated rats (red bars). Gray bars denote the CS period. *P < 0.05 vs. vehicle. All error bars indicate mean ± SEM.