Fig. 9.

BACE1 is enriched in LAMP1-positive axonal swellings at amyloid plaques. (A) WT cerebral cortex stained for BACE1 and LAMP1 shows their distinct patterns of localization. (B) 5xFAD cerebral cortex (in 3- and 6-mo-old animals) showing coaccumulation of LAMP1 and BACE1 (arrowheads, 3-mo-old sample) in dystrophic axons. (Scale bars: 10 μm.) (C) Schematic diagram that summarizes the distribution of lysosomes and their relative content of luminal proteases in healthy neurons as well as in AD neurons whose axons make contact with extracellular Aβ deposits.