Fig. S2.

Investigation of the effect of amyloid plaques on vGLUT1 and cation-independent mannose-6-phosphate receptor (CI-M6PR) localization (related to Fig. 3). (A) Representative images of 5xFAD cortex (6-mo) costained for vGLUT1 and LAMP1. (B) Representative staining for M6PR and LAMP1 in WT cerebral cortices of 6-mo-old mice. (C) Representative staining for M6PR and LAMP1 (high-magnification image) and composite images of 5xFAD cerebral cortex and hippocampus. CI-M6PR shows limited enrichment at sites of major LAMP1 accumulation. (Scale bars: 10 µm.)