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The endogenous FBXO31–MDM2 interaction is lost following treatment of IMR90 cells with the ATM inhibitor KU-55933. Coimmunoprecipitation analysis monitoring the endogenous FBXO31–MDM2 interaction in IMR90 cells treated in the presence or absence of camptothecin or KU-55933. Extracts were immunoprecipitated with an FBXO31 or MDM2 antibody.
