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. 2015 Jun 29;112(28):8774–8779. doi: 10.1073/pnas.1503395112

Fig. 2.

Fig. 2.

Mitogenic signaling of HU-433 in osteoblasts involves CB2 and its downstream signaling pathway. (A and B) Number of wild-type (WT) (♦) and CB2−/− (♢) newborn mouse calvarial osteoblasts by HU-433 (A) and HU-308 (B). (C) DNA synthesis. (D and E) inhibition of HU-433 (D) and HU-308 (E) stimulated cell number by CB2 antagonist SR144528 (SR2). (F and G) Inhibition of HU-433 stimulated cell number by pertussis toxin (PTX) (F) and MEK/Erk1,2 inhibitor PD98059 (G). (H) Stimulation of Mapkapk2 mRNA levels by HU-433. Data are mean ± SE obtained in triplicate culture wells per condition. *P < 0.05 vs. Cntl (control).