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HU-433 attenuates xylene-induced ear swelling in WT, but not CB2-deficient, mice. (A) WT mice. (B) CB2−/− mice. ■, VEH; ◆, HU-433; ▲, Indomethacin. Data are mean ± SE obtained in six mice per condition. *P < 0.05 vs. VEH-treated mice.