Table 1.

Alteration in CpG and UpA dinucleotide frequencies on optimization for insect cell codon pair use

Sequence	Region	Position	Length (%)*	CpG (O/E)†	UpA (O/E)†
Wild-type	E	940–2421	1,482 (14.0%)	20 (0.268)	55 (0.528)
Recoded				87 (1.164)	86 (0.817)
Wild-type	NS3	4528–6042	1,515 (14.1%)	32 (0.404)	68 (0.652)
Recoded				99 (1.252)	111 (1.062)
Wild-type	NS5	7576–9942	2,367 (22.1%)	62 (0.516)	91 (0.566)
Recoded				147 (1.229)	134 (0.832)

^*Length and proportion of genome modified.

^†Numbers of CpG and UpA dinucleotides (observed/expected ratio in parentheses); increased numbers indicated in bold.