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. Author manuscript; available in PMC: 2016 Jan 16.
Published in final edited form as: Nat Commun. 2015 Jul 16;6:7530. doi: 10.1038/ncomms8530

Figure 6. Targeting c-Myc is a mechanism by which 14-3-3σ suppresses cancer metabolic reprogramming.

Figure 6

(a) c-Myc expression was knocked down in MDA-MB-231 TetR 14-3-3σ breast cancer cells.

(b–c) c-Myc knockdown hindered 14-3-3σ–mediated suppression of cancer metabolic reprogramming. MDA-MB-231 TetR 14-3-3σ cells infected with luciferase shRNA, c-Myc shRNA #1614, or c-Myc shRNA #1657 were treated with doxycycline to induce Flag-14-3-3σ expression (+). Non-induced cells were used as a control (−). ECAR and OCR were measured as previously described. Bars represent means ± 95% CI; Student t-test, * p < 0.05.