FIG. 5.

iPSC graft extension and functional assessment of left ventricle (LV) function 14 days after intramyocardial transplantation of iPSCs in myocardial infarction. (A) Infarct extension (dashed yellow line) in the infarct-control group was quantified as percentage of the whole LV (red) circumference. Right ventricle is marked by the blue line. (B) Medium-treated animals showed several smaller grafts (marked in green) in the LV. (C) In the fibrinogen group grafts were bigger and confined to one part of the LV. (D) There was no difference regarding the extension of infarcted myocardium following experimental infarction by left anterior descending artery ligation. (E) Both cellular groups showed cardiac engraftment of iPSCs. However, graft size (% of the infarcted circumference of the LV) was superior in the fibrinogen group. (F) Both cellular groups showed improvement of the left ventricular ejection fraction (LV-EF), as measured by MRI on day 14. Functional improvement is related to ventricular geometry and correlates with the extent of refilled infarction. Color images available online at www.liebertpub.com/tea