Table II.

Hazard ratios (HR) with 95% confidence intervals (CI) of overall cancer for ART women compared with non-ART women. All women with a cancer at any site prior to inclusion were omitted from analyses.

	ART women		Non-ART women		HR	Lower CI	Upper CI
	N	p.yrs	N	p.yrs
Crude risk	338	139 776	21 944	12 162 146	*1.23	1.11	1.37
Adjusted riska	338	139 776	21 944	12 162 146	*1.16	1.04	1.29
Excl. cancer during the first yearb	329	139 770	21 610	12 161 963	*1.16	1.04	1.30
Age at follow-up, years
30–40	133	86 928	7868	8 273 366	*1.25	1.05	1.49
40–50	173	46 773	9075	3 074 518	*1.21	1.04	1.42
≥50	32	6074	5001	814 262	0.84	0.59	1.20
Total	338	139 775	21 944	12 162 146
Parity at entry
P0	302	128 250	13 024	8 827 019	*1.17	1.04	1.32
P1+	36	11 527	8920	3 335 126	1.19	0.85	1.65
Total	338	139 777	21 944	12 162 145
Parity at exit
One	163	78 480	4133	3 673 723	1.07	0.91	1.26
Two	138	49 014	9233	4 842 584	*1.23	1.04	1.46
Three or more	37	12 282	8578	3 645 839	1.37	0.99	1.90
Total	338	139 776	21 944	12 162 146
Calendar year at follow-up
1983–1992	6	3778	1561	1 972 460	1.51	0.68	3.39
1993–2002	71	40 547	6723	4 777 423	1.06	0.83	1.34
2003–2010	261	95 451	13 660	5 412 262	*1.18	1.05	1.34
Total	338	139 776	21 944	12 162 145
Method of ART
IVF	257	96 017	21 944	12 162 146	*1.22	1.07	1.38
ICSI	45	28 632	21 944	12 162 146	0.98	0.73	1.32
Other	36	15 127	21 944	12 162 146	1.03	0.75	1.43
Total	338	139 776
Duration of follow-up, years
<1 year	11	13 240	349	791 255	0.84	0.59	1.20
1–5	63	44 411	2221	2 903 417	1.14	0.86	1.44
>5–10	102	39 949	3821	3 033 330	*1.23	1.01	1.51
>10	162	42 176	15 553	5 434 144	1.14	0.97	1.33
Total	338	139 776	21 944	12 162 146

^aHazard ratios are adjusted for attained age, age at start of follow-up, parity, region of residence and calendar period.

^bThose with cancer diagnosed within the first year of follow-up were omitted from this analysis.

Number of cancers in each group (n), person years (p.yrs).

*Hazard rates which were statistically significant between ART and non-ART women, lost statistical significance once corrections were made for multiple analyses, using the Benjamini-Hochberg method.