Skip to main content
. 2015 Jun 24;30(8):1952–1963. doi: 10.1093/humrep/dev124

Table II.

Hazard ratios (HR) with 95% confidence intervals (CI) of overall cancer for ART women compared with non-ART women. All women with a cancer at any site prior to inclusion were omitted from analyses.

ART women
Non-ART women
HR Lower CI Upper CI
N p.yrs N p.yrs
Crude risk 338 139 776 21 944 12 162 146 *1.23 1.11 1.37
Adjusted riska 338 139 776 21 944 12 162 146 *1.16 1.04 1.29
Excl. cancer during the first yearb 329 139 770 21 610 12 161 963 *1.16 1.04 1.30
Age at follow-up, years
 30–40 133 86 928 7868 8 273 366 *1.25 1.05 1.49
 40–50 173 46 773 9075 3 074 518 *1.21 1.04 1.42
 ≥50 32 6074 5001 814 262 0.84 0.59 1.20
 Total 338 139 775 21 944 12 162 146
Parity at entry
 P0 302 128 250 13 024 8 827 019 *1.17 1.04 1.32
 P1+ 36 11 527 8920 3 335 126 1.19 0.85 1.65
 Total 338 139 777 21 944 12 162 145
Parity at exit
 One 163 78 480 4133 3 673 723 1.07 0.91 1.26
 Two 138 49 014 9233 4 842 584 *1.23 1.04 1.46
 Three or more 37 12 282 8578 3 645 839 1.37 0.99 1.90
 Total 338 139 776 21 944 12 162 146
Calendar year at follow-up
 1983–1992 6 3778 1561 1 972 460 1.51 0.68 3.39
 1993–2002 71 40 547 6723 4 777 423 1.06 0.83 1.34
 2003–2010 261 95 451 13 660 5 412 262 *1.18 1.05 1.34
 Total 338 139 776 21 944 12 162 145
Method of ART
 IVF 257 96 017 21 944 12 162 146 *1.22 1.07 1.38
 ICSI 45 28 632 21 944 12 162 146 0.98 0.73 1.32
 Other 36 15 127 21 944 12 162 146 1.03 0.75 1.43
 Total 338 139 776
Duration of follow-up, years
 <1 year 11 13 240 349 791 255 0.84 0.59 1.20
 1–5 63 44 411 2221 2 903 417 1.14 0.86 1.44
 >5–10 102 39 949 3821 3 033 330 *1.23 1.01 1.51
 >10 162 42 176 15 553 5 434 144 1.14 0.97 1.33
 Total 338 139 776 21 944 12 162 146

aHazard ratios are adjusted for attained age, age at start of follow-up, parity, region of residence and calendar period.

bThose with cancer diagnosed within the first year of follow-up were omitted from this analysis.

Number of cancers in each group (n), person years (p.yrs).

*Hazard rates which were statistically significant between ART and non-ART women, lost statistical significance once corrections were made for multiple analyses, using the Benjamini-Hochberg method.