Table II.
Hazard ratios (HR) with 95% confidence intervals (CI) of overall cancer for ART women compared with non-ART women. All women with a cancer at any site prior to inclusion were omitted from analyses.
ART women |
Non-ART women |
HR | Lower CI | Upper CI | |||
---|---|---|---|---|---|---|---|
N | p.yrs | N | p.yrs | ||||
Crude risk | 338 | 139 776 | 21 944 | 12 162 146 | *1.23 | 1.11 | 1.37 |
Adjusted riska | 338 | 139 776 | 21 944 | 12 162 146 | *1.16 | 1.04 | 1.29 |
Excl. cancer during the first yearb | 329 | 139 770 | 21 610 | 12 161 963 | *1.16 | 1.04 | 1.30 |
Age at follow-up, years | |||||||
30–40 | 133 | 86 928 | 7868 | 8 273 366 | *1.25 | 1.05 | 1.49 |
40–50 | 173 | 46 773 | 9075 | 3 074 518 | *1.21 | 1.04 | 1.42 |
≥50 | 32 | 6074 | 5001 | 814 262 | 0.84 | 0.59 | 1.20 |
Total | 338 | 139 775 | 21 944 | 12 162 146 | |||
Parity at entry | |||||||
P0 | 302 | 128 250 | 13 024 | 8 827 019 | *1.17 | 1.04 | 1.32 |
P1+ | 36 | 11 527 | 8920 | 3 335 126 | 1.19 | 0.85 | 1.65 |
Total | 338 | 139 777 | 21 944 | 12 162 145 | |||
Parity at exit | |||||||
One | 163 | 78 480 | 4133 | 3 673 723 | 1.07 | 0.91 | 1.26 |
Two | 138 | 49 014 | 9233 | 4 842 584 | *1.23 | 1.04 | 1.46 |
Three or more | 37 | 12 282 | 8578 | 3 645 839 | 1.37 | 0.99 | 1.90 |
Total | 338 | 139 776 | 21 944 | 12 162 146 | |||
Calendar year at follow-up | |||||||
1983–1992 | 6 | 3778 | 1561 | 1 972 460 | 1.51 | 0.68 | 3.39 |
1993–2002 | 71 | 40 547 | 6723 | 4 777 423 | 1.06 | 0.83 | 1.34 |
2003–2010 | 261 | 95 451 | 13 660 | 5 412 262 | *1.18 | 1.05 | 1.34 |
Total | 338 | 139 776 | 21 944 | 12 162 145 | |||
Method of ART | |||||||
IVF | 257 | 96 017 | 21 944 | 12 162 146 | *1.22 | 1.07 | 1.38 |
ICSI | 45 | 28 632 | 21 944 | 12 162 146 | 0.98 | 0.73 | 1.32 |
Other | 36 | 15 127 | 21 944 | 12 162 146 | 1.03 | 0.75 | 1.43 |
Total | 338 | 139 776 | |||||
Duration of follow-up, years | |||||||
<1 year | 11 | 13 240 | 349 | 791 255 | 0.84 | 0.59 | 1.20 |
1–5 | 63 | 44 411 | 2221 | 2 903 417 | 1.14 | 0.86 | 1.44 |
>5–10 | 102 | 39 949 | 3821 | 3 033 330 | *1.23 | 1.01 | 1.51 |
>10 | 162 | 42 176 | 15 553 | 5 434 144 | 1.14 | 0.97 | 1.33 |
Total | 338 | 139 776 | 21 944 | 12 162 146 |
aHazard ratios are adjusted for attained age, age at start of follow-up, parity, region of residence and calendar period.
bThose with cancer diagnosed within the first year of follow-up were omitted from this analysis.
Number of cancers in each group (n), person years (p.yrs).
*Hazard rates which were statistically significant between ART and non-ART women, lost statistical significance once corrections were made for multiple analyses, using the Benjamini-Hochberg method.