Table III.

Risk of cervical and ovarian cancer for ART women compared with non-ART women, stratified analyses.

	Cervical cancer (C53)					Ovarian cancer (C56)
	ART	Non-ART	HR	Lower bound	Upper bound	ART	Non-ART	HR	Lower bound	Upper bound
	n	n				n	n
Number of cancers during the observational period	24	2156				16	800
Crude risk	24	2156	0.83	0.55	1.24	16	800	1.67	1.02	2.74
Adjusted riska	24	2156	0.86	0.57	1.29	16	800	1.56	0.94	2.60
Excl. cancer during the first yearb	23	2102	0.87	0.58	1.32	14	781	1.43	0.83	2.45
Parity at entry
P0	19	1459	0.78	0.50	1.24	14	402	*1.80	1.04	3.11
P1+	5	697	2.03	0.84	4.93	2	398	1.60	0.40	6.45
Total	24	2156				16	800
Parity at exit
One	15	498	0.99	0.59	1.67	12	172	*2.00	1.08	3.65
Two	9	910	0.85	0.44	1.64	3	305	0.95	0.30	2.98
Three or more	0	748	NA	–	–	1	323	1.22	0.17	8.71
Total	24	2156				16	800
Method of ART
IVF	17	2156	0.88	0.55	1.43	11	800	1.45	0.79	2.65
ICSI	4	2156	0.70	0.26	1.88	2	800	1.51	0.37	6.11
Other	3	2156	1.04	0.33	3.22	3	800	2.33	0.75	7.28
Total	24					16
Duration of follow-up, years
<1 year	2	56	1.08	0.25	4.54	2	19	*5.59	1.12	28.0
1–5	11	317	1.70	0.91	3.15	3	73	2.01	0.60	6.67
>5–10	9	608	1.10	0.57	2.15	6	133	1.98	0.85	4.64
>10	2	1175	0.20	0.05	0.81	5	575	0.96	0.39	2.33
Total	24	2156				16	800

^aHazard ratios are adjusted for attained age, age at start of follow-up, parity, region of residence and calendar period.

^bThose with an index cancer diagnosed within the first year of follow-up were omitted from this analysis.

*Hazard rates which were statistically significant between ART and non-ART women, lost statistical significance once corrections were made for multiple analyses, using the Benjamini-Hochberg method.