Table V.
Risk of colorectal and thyroid cancer for ART women compared with non-ART women, stratified analyses.
| Colorectal cancer (C18-20) |
Thyroid cancer (C73) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ART | Non-ART | HR | Lower bound | Upper bound | ART | Non-ART | HR | Lower bound | Upper bound | |
| n | n | n | n | |||||||
| Number of cancers during the observational period | 25 | 1364 | 13 | 919 | ||||||
| Crude risk | 22 | 1364 | 1.36 | 0.89 | 2.07 | 13 | 919 | 1.14 | 0.66 | 1.97 |
| Adjusted riska | 22 | 1364 | 1.31 | 0.85 | 2.01 | 13 | 919 | 1.15 | 0.66 | 2.00 |
| Excl. cancer during the first yearb | 22 | 1354 | 1.34 | 0.87 | 2.06 | 13 | 894 | 1.18 | 0.68 | 2.06 |
| Parity at entry | ||||||||||
| P0 | 20 | 659 | 1.43 | 0.91 | 2.25 | 12 | 640 | 1.07 | 0.60 | 1.91 |
| P1+ | 2 | 705 | 0.90 | 0.22 | 3.60 | 1 | 279 | 0.97 | 0.13 | 6.93 |
| Total | 22 | 1364 | 13 | 919 | ||||||
| Parity at exit | ||||||||||
| One | 9 | 183 | 1.13 | 0.57 | 2.23 | 3 | 201 | 0.50 | 0.15 | 1.55 |
| Two | 10 | 572 | 1.41 | 0.75 | 2.65 | 7 | 403 | 1.59 | 0.75 | 3.39 |
| Three or more | 3 | 609 | 1.81 | 0.58 | 5.64 | 3 | 315 | 2.60 | 0.83 | 8.15 |
| Total | 22 | 1364 | 13 | 919 | ||||||
| Method of ART | ||||||||||
| IVF | 16 | 1364 | 1.27 | 0.77 | 2.10 | 9 | 919 | 1.15 | 0.59 | 2.23 |
| ICSI | 2 | 1364 | 0.95 | 0.24 | 3.80 | 2 | 919 | 0.87 | 0.22 | 3.51 |
| Other | 4 | 1364 | 1.86 | 0.69 | 4.98 | 2 | 919 | 1.59 | 0.40 | 6.40 |
| Total | 22 | 13 | ||||||||
| Duration of follow-up, years | ||||||||||
| <1 year | 0 | 10 | NA | – | – | 0 | 26 | NA | – | – |
| 1–5 | 6 | 81 | 2.27 | 0.96 | 5.41 | 3 | 186 | 0.82 | 0.26 | 2.61 |
| >5–10 | 5 | 158 | 1.13 | 0.46 | 2.82 | 3 | 238 | 0.81 | 0.26 | 2.58 |
| >10 | 11 | 1115 | 1.16 | 0.64 | 2.12 | 7 | 469 | 1.84 | 0.87 | 3.93 |
| Total | 22 | 1364 | 13 | 919 | ||||||
aHazard ratios are adjusted for attained age, age at start of follow-up, parity, region of residence and calendar period.
bThose with an index cancer diagnosed within the first year of follow-up were omitted from this analysis.