FIG 1.

Summary of bioinformatic analyses of R. capsulatus ComEC, ComF, and ComM proteins. (A) Comparison of S. pneumoniae ComEC to R. capsulatus ComEC. (B) Comparison of H. influenzae ComF to R. capsulatus ComF. (C) Comparison of R. capsulatus ComM to H. influenzae ComM. Amino acid numbers and domains are indicated. DUF4131 is a functionally uncharacterized domain found frequently in the N-terminal section of ComEC homologues; pfam03772 is an uncharacterized domain ubiquitously present in ComEC homologues; smart00849, present in many ComEC homologues, may bind zinc ions as a cofactor (14); DZR stands for the double zinc ribbon domain most often involved in DNA binding in transcriptional regulators (38); PRTase stands for phosphoribosyltransferase, a domain often involved in nucleotide salvage pathways (37); MgCh-ChlI stands for magnesium chelatase subunit ChlI, an AAA+ ATPase that provides energy for insertion of Mg²⁺ into protoporphyrin IX (40); RvuB is a domain found in some Holliday junction DNA helicases (41); MCM2/3/5 stands for maintenance of minichromosomes and functions in the replication of genomes (42).