Table 1.
Genomic Organization and Biological Character Comparison of SC0806 and Representatives of Recognized Orthobunyavirus Serogroups
| L segment | M segment | S segment | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serogroups | Species | Virus | 5′-UTR (nt) | ORF (nt)/RdRp (aa) | 3′-UTR (nt) | 5′-UTR (nt) | ORF (nt)/Polyprotein (aa) | 3′-UTR (nt) | 5′-UTR (nt) | ORF (nt)/NP (aa) | ORF (nt)/NSs (aa) | 3′-UTR (nt) | Natural Host Range | Human disease | Distribution |
| Simbu | Manzanilla | SC0806 | 56 | 6783/2261 | 86 | 43 | 4299/1433 | 136 | 44 | 699/233 | 285/95 | 238 | Mosquitoes | Febrile illness? | China |
| Manzanilla | Cat Que virus | 56 | 6783/2261 | 84 | 43 | 4299/1433 | 136 | 44 | 699/233 | 285/95 | 237 | Mosquitoes | No human pathology has been documented | Vietnam | |
| Manzanilla | TRVL 3586 | 59 | 6783/2261 | 71 | 55 | 4299/1433 | 159 | 44 | 699/233 | 285/95 | 236 | Mosquitoes, alouatta seniculus | Febrile illness | Trinidad | |
| Akabane | OBE-1 | 30 | 6753/2251 | 82 | 22 | 4203/1401 | 81 | 33 | 699/233 | 273/91 | 123 | Mosquitoes, cattle | Febrile illness | Japan, Australia, Kenya, Taiwan, Viet Nam, Bandung, Thailand | |
| Oropouche | TRVL-9760 | 31 | 6756/2252 | 21 | 17 | 4260/1420 | 77 | 44 | 693/231 | 273/91 | 9 | Mosquitoes, human, livestock, bradypus tridactylus, culicoides | Febrile illness with central nervous system signs (including encephalitis) | Trinidad, Brazil, Colombia | |
| Sathuperi | Sathuperi virus | 18 | 6762/2254 | 78 | 6 | 4209/1403 | 112 | 43 | 699/233 | 273/91 | 98 | Mosquitoes, human, cattle, culicoides, | Febrile illness | India, Nigeria | |
| Simbu | SA Ar 53 | 21 | 6759/2253 | 112 | 13 | 4227/1409 | 174 | 24 | 699/233 | 273/91 | 134 | Mosquitoes, human, | Febrile illness | South Africa, Senegal, Cameroun, Central African Republic, Botswana | |
| Shamonda | An5550 | 19 | 6762/2254 | 79 | 17 | 4209/1403 | 85 | 30 | 699/233 | 273/91 | 195 | Cattle | Febrile illness | Nigeria | |
| Shuni | An10107 | 12 | 6759/2253 | 106 | 11 | 4212/1404 | 100 | 34 | 699/233 | 273/91 | 114 | Mosquitoes, human, cattle, sheep, culicoides | Febrile illness | Nigeria, South Africa | |
| Bunyamwera | Bunyamwera | Bunyamwera virus | 50 | 6714/2238 | 108 | 56 | 4299/1433 | 100 | 85 | 699/233 | 303/101 | 174 | Human, chimpanzee, monkeys, domestic animals, rodents, birds | Febrile illness with rash or central nervous system signs (including encephalitis) | South Africa, Uganda, Nigeria, Cameroun, Central African Republic, Kenya, Senegal, Congo, Senegal, Mozambique, Egypt, Tunisia, Tanzania, Angola |
| California encephalitis | California encephalitis | La Crosse virus | 61 | 6789/2263 | 127 | 61 | 4323/1441 | 138 | 79 | 705/235 | 276/92 | 195 | Mosquitoes | Febrile illness with central nervous system signs (including encephalitis) | California, Utah, New Mexico, Texas, USA, Manitoba, Canada |
| Wyeomyia | Wyeomyia | Wyeomyia virus | 36 | 6708/2236 | 107 | 20 | 4251/1417 | 266 | 71 | 699/233 | 78/26* | 294 | Mosquitoes, human | Febrile illness | Colombia, Panama, Trinidad, Brazil, French Guiana |
Note: GenBank accession numbers used: SC0806, JX983192–JX983194; Cat Que virus, JQ675598–JQ675600; TRVL 3586, KF697148–KF697150; OBE-1, NC009894–NC009896; TRVL-9760, KC759122–KC759124; Sathuperi virus, HE795102–HE795104; SA Ar 53, NC018476–NC018478; An5550, HE795105–HE795107; An10107, HE800141–HE800143; Bunyamwera virus, NC001925–NC001927; La Crosse virus, GU206144–GU206146; Wyeomyia virus, JN572080–JN572082.
Truncated open reading frame (ORF) that may not be expressed.
The distribution, natural host range, and human disease of each serogroup are based on the documentation in ArboCAT (wwwn.cdc.gov/arbocat).
L segment, large RNA segment; M segment, medium RNA segment; S segment, small RNA segment; UTR, untranslated region; ORF, open reading frame; nt, nucleotides; aa, amino acids.