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. 2015 Jul 1;29(7):810–815. doi: 10.1089/end.2014.0585

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Copyright 2015, Mary Ann Liebert, Inc.

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FIG. 4. — Representative histopathology of histotripsy-treated canine prostate. (A) A composite image of a histotripsy-treated canine prostate (subject 7). Anterior (Ant.) and posterior (Post.) are indicated, along with the treated and untreated sides. The urethra (U) and cavitation cavity (C) are noted. Minimal interstitial inflammation was noted in the treated and untreated sides in this subject. Indicated areas shown in dashed black and green boxes are shown as insets in B and C. (B) The reepithelialized cavitation cavity is surrounded by fibromuscular stroma similar in appearance to that surrounding the urethra. (C) Foci of atrophic glands and basal cell hyperplasia surround the cavitation cavity, reminiscent of periurethral ducts/glands. In addition, areas of unremarkable prostate glands were also adjacent to the cavitation cavity. Higher power view of atrophy and basal cell hyperplasia with surrounding minimal interstitial chronic inflammation is shown in the inset. Original magnifications 1.25× (A), 4× (B), 10× (C), and 20× (inset of C).