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. 2015 Apr 13;24(15):1751–1765. doi: 10.1089/scd.2014.0489

FIG. 7.

FIG. 7.

Otx2 is required for T3-induced Ngn2 and Nurr1 activation. (A–C) VM NSCs were treated with T3 for 1 or 2 days. The protein level of Ngn2 and Nurr1 was detected. Images in (A) are representative western blot bands from four independent experiments. (B, C) Indicate the fold changes in protein levels compared to the control. (D–F) Pregnant mice were treated with PTU. The protein level of Ngn2 and Nurr1 was detected at E13.5 and P0. Images in (D) are representative bands from four independent experiments. (E, F) The statistical results of the protein expression of Ngn2 and Nurr1. (G–I) NSCs were transfected with control-siRNA or Otx2-siRNA. T3 was administered to induce differentiation. Graphs contain the representative protein bands and statistical results of Ngn2 and Nurr1 from four independent experiments. For all experiments, data are presented as the mean±SEM. n=4, one-way ANOVA followed by Fisher's post hoc test, *P<0.05, **P<0.01.