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Association of partial EMT with stemness. (A) “EMT gradient” model proposed by Ombrato and Malanchi (134) where stemness is maintained within a window between a fully differentiated epithelial cell and a fully de-differentiated mesenchymal cell [Figure adapted from Ref. (134), cartoons included]. (B) Stemness or tumor-initiating potential of E, E/M, and M phenotype, or variation of stemness during EMT progression (brown line).
