Table A1.

Required Observations

Observation	Induction Chemotherapy	Second-Look Surgery	Radiation Therapy	End Therapy	Follow-Up
					Year 1	Year 2
MRI (brain with or without spine)	Before cycles 3 and 5 and after cycle 6	Post		Brain and spine	Every 3 months	Every 4 months
Tumor markers (serum and CSF)	Before each cycle	Post	Prior	Serum	Every 3 months	Every 4 months
Endocrine evaluation	Baseline				At 6 and 12 months	At 24 months
Ophthalmologic evaluation	Baseline

NOTE. Magnetic resonance imaging (MRI) scan with gadolinium of the entire spine is required within 10 days before or at least 10 days after surgery with contrast (and without contrast if scan is postoperative). Only an MRI with contrast of the spine is required at study entry if there was no surgery (nonhistologic confirmation with markers). All brain postoperative imaging should be done within 48 hours of surgery. If imaging cannot be obtained at that time, then it should be done within 28 days after surgery. Postinduction MRI will serve as preradiation therapy evaluation. Endocrine evaluations consists of free thyroxine, thyroid-stimulating hormone, insulinlike growth factor 1, insulinlike growth factor-binding protein 3, bone age, lactate dehydrogenase (in males older than age 10 years or in females older than age 9 years), follicle-stimulating hormone (in males older than age 10 years or in females older than age 9 years), testosterone (in males older than age 10 years), estradiol (in females older than age 9 years), Tanner stage, human chorionic gonadotropin, cortisol at 8:00 to 10:00 am cortisol.