Table 2.
Pulmonary hemodynamics at rest of 139 patients grouped according to the GOLD spirometric grades
| All | GOLD grade
|
ANOVA P-value |
|||
|---|---|---|---|---|---|
| 2 | 3 | 4 | |||
| N | 139 | 46 | 56 | 37 | |
| mPAP (mmHg) | 20±8 | 18±6 | 21±9 | 21±6 | NS |
| PCWP (mmHg) | 6±4 | 7±4 | 6±4 | 5±3 | NS |
| RAP (mmHg) | 2.9±3.2 | 3.4±3.5 | 2.1±3.2 | 2.7±2.7 | NS |
| CO (L/min/m2) | 5.6±1.4 | 6.3±1.5 | 5.5±1.3* | 4.7±0.8*,≠ | <0.001 |
| CI (L/min/m2) | 3.2±0.8 | 3.6±0.8 | 3.1±0.7* | 2.8±0.6*,≠ | <0.001 |
| TPR (dyn⋅s⋅cm−5) | 306±158 | 244±105 | 322±197* | 355±191*,≠ | 0.004 |
| PVR (dyn⋅s⋅cm−5) | 218±143 | 160±88 | 233±185* | 264±97*,≠ | 0.003 |
| TPG | 14±7 | 12±5 | 15±8 | 16±5*,≠ | 0.02 |
| Patients with PH, n (%) | 25 (18) | 3 (7) | 14 (25) | 8 (22) | |
Notes: Data are presented as mean ± standard deviation. Significant differences within each variable are indicated as:
*
different from GOLD grade 2;
≠
different from GOLD grade 3.
Abbreviations: ANOVA, analysis of variance; CI, cardiac index; CO, cardiac output; GOLD, Global Initiative for Chronic Obstructive Pulmonary Disease; mPAP, mean pulmonary artery pressure; NS, not significant; PCWP, pulmonary capillary wedge pressure; PH, pulmonary hypertension; PVR, pulmonary vascular resistance; RAP, right atrial pressure; TPG, transpulmonary pressure gradient; TPR, total pulmonary resistance.