Table 4.
Pulmonary hemodynamics during submaximal exercise in patients grouped to the GOLD spirometric grades (n=85)
| All | GOLD grade
|
ANOVA P-value | |||
|---|---|---|---|---|---|
| 2 | 3 | 4 | |||
| Hemodynamics during exercise, N | 85 | 40 | 39 | 6 | |
| mPAP (mmHg) | 42±14 | 38±11 | 45±15 | 52±7 | 0.019 |
| PCWP (mmHg) | 20±9 | 19±9 | 21±10 | 20±6 | NS |
| CO (L/min/m2) | 11.8±2.8 | 12.2±2.8 | 11.7±2.8 | 9.5±2.2 | NS |
| CI (L/min/m2) | 6.5±1.5 | 6.7±1.5 | 6.3±1.5 | 5.4±1.1 | NS |
| TPR (dyn⋅s⋅cm−5) | 315±174 | 265±105 | 345±215 | 454±146* | 0.014 |
| PVR (dyn⋅s⋅cm−5) | 171±134 | 136±72 | 191±173 | 274±86 | 0.02 |
| TPG (mmHg) | 22±11 | 19±8 | 24±13 | 31±7* | 0.02 |
| ΔmPAP/ΔCO (mmHg/L/min) | 4.8±3.7 | 4.1±2.2 | 5.4±4.8 | 6.4±2.7 | |
| Abnormal mPAPa, n (%) | 29 (34) | 8 (20) | 17 (46) | 4 (67) | |
| ΔmPAP/ΔCO >3, n (%) | 60 (71) | 28 (70) | 26 (67) | 6 (100) | |
Notes: Data are presented as mean ± standard deviation.
a
mPAP: <50 years, >30 mmHg; ≥50 years, >46 mmHg. According to Kovacs et al.26 Significant differences within each variable are indicated as:
*
different from GOLD grade 2.
Abbreviations: GOLD, Global Initiative for Chronic Obstructive Pulmonary Disease; Δ, change; ANOVA, analysis of variance; CI, cardiac index; CO, cardiac output; mPAP, mean pulmonary artery pressure; NS, not significant; PCWP, pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; TPG, transpulmonary pressure gradient; TPR, total pulmonary resistance.